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History of epidemiology

 

Pierre Charles Alexandre Louis (1787-1872)

 

ARTICLES

 

MORABIA A. Pierre-Charles-Alexandre Louis and the birth of clinical epidemiology. J Clin Epidemiol 1996; 49:1327-1333.

MORABIA A., ROCHAT T. Reproducibility of Louis' definition of pneumonia [letter]. Lancet 2001; 358:1188.

Morabia A. Pierre-Charles-Alexandre Louis and the evaluation of bloodletting. The James Lind Library (www.jameslindlibrary.org), 2004

Morabia A . Pierre-Charles-Alexandre Louis and the evaluation of bloodletting. J R Soc Med 2006;99:158-160.

 

TEACHING MATERIAL


The table below is a compilation of the data reported by Louis in the English version of “Researches on the effects of bloodletting in some inflammatory diseases”. In the English version of the book some typographical errors present in the French version have been corrected. You can use these data to re-analyze Louis’s study either as a “case-control” comparison, using the outcome as the fixed variable, or as the follow-up of patients with either early (1-4 days) or late (>4 days) bleeding after onset of disease. Using the variable duration of disease, you may also perform a survival analysis, as in Morabia (1996) and in Hill (1997).

Column 1: Duration of disease (days)

Column 2: Outcome 0=alive (n=50), 1=dead (n=27)

Colum 3: Bleeding 0=early (n=41), 1= late (n=36)


4 1 0
6 1 0
6 1 0
6 1 0
7 0 0
8 1 0
8 1 1
9 1 1
10 0 0
10 0 0
10 1 1
11 1 0
11 0 1
12 0 0
12 0 0
12 0 0
12 0 0
12 0 0
12 1 0
12 1 0
12 1 0
12 0 1
12 0 1
13 0 1
13 0 1
13 0 1
13 0 1
14 0 0
15 0 0
15 1 0
15 0 1
16 0 0
16 0 0
16 1 0
16 0 1
16 1 1
17 0 0
17 1 0
17 1 0
17 0 1
17 0 1
17 0 1
18 0 1
18 0 1
19 0 0
19 0 0
19 0 1
19 0 1
20 0 0
20 0 0
20 1 0
20 0 1
20 1 1
21 0 0
21 0 1
21 0 1
22 0 0
22 1 1
23 0 1
24 0 1
25 0 0
25 1 1
27 0 1
28 0 0
28 0 1
29 0 0
29 1 0
29 1 0
29 1 1
30 0 1
35 0 1
35 0 1
40 0 0
40 0 1
47 1 0
53 1 0
62 1 1

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